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Larotrectinib (By mouth)

Larotrectinib (lar-oh-TREK-ti-nib)

Treats solid tumors.

Brand Name(s):

Vitrakvi

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use it if you had an allergic reaction to larotrectinib, or if you are pregnant or breastfeeding.

How to Use This Medicine:

Capsule, Liquid

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • Swallow the capsule whole with water. Do not chew, crush, or open it.
  • Oral liquid: Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.
  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
  • Missed dose: Take a dose as soon as you remember. If your next regular dose is in 6 hours or less, skip the missed dose and return to your regular dosing schedule. If you vomit after taking a dose, take the next dose at the regular time.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Store the oral liquid in the refrigerator. Do not freeze. Throw away any unused oral liquid after 90 days of first opening the bottle.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Some medicines can affect how larotrectinib works. Tell your doctor if you are using St John's wort.
  • Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

Warnings While Using This Medicine:

  • This medicine may cause birth defects if either partner is using it during conception or pregnancy. Tell your doctor right away if you or your partner becomes pregnant. Use an effective form of birth control during treatment with this medicine and for at least 1 week after the last dose. Male patients with female partners should use an effective form of birth control during treatment and for 1 week after the last dose.
  • Do not breastfeed during treatment with this medicine and for 1 week after the last dose.
  • Tell your doctor if you have liver disease or brain or nerve problems.
  • This medicine may cause liver problems.
  • This medicine may make you dizzy, confused, or less alert than you are normally. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
  • Talk with your doctor before using this medicine if you plan to have children. Some women who use this medicine have become infertile (unable to have children).
  • Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
  • Cancer medicine can cause nausea or vomiting, sometimes even after you receive medicine to prevent these effects. Ask your doctor or nurse about other ways to control any nausea or vomiting that might happen.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
  • Confusion, difficulty speaking, dizziness, loss of balance or unsteadiness, tremors
  • Numbness, tingling, or burning pain in your hands, arms, legs, or feet

If you notice these less serious side effects, talk with your doctor:

  • Constipation, diarrhea
  • Headache
  • Increased weight
  • Joint or muscle pain or weakness

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 3/19/2020

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