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Midostaurin (By mouth)

Midostaurin (mye-doe-STAW-rin)

Treats leukemia. Also treats a rare disorder called aggressive systemic mastocytosis or mast cell leukemia.

Brand Name(s):

Rydapt

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use it if you had an allergic reaction to midostaurin, or if you are pregnant.

How to Use This Medicine:

Liquid Filled Capsule

  • Your doctor will tell you how much medicine to use. Do not use more than directed.
  • It is best to take this medicine with food or milk.
  • Swallow the capsule whole. Do not crush, break, chew, or open it.
  • You may also receive medicines to help prevent nausea and vomiting.
  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
  • Missed dose:
    • This medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor for instructions.
    • If you missed a dose or vomit after taking your medicine, do not take an extra dose. Take your next dose at your scheduled dose.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Store the medicine in the original package to protect from moisture.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Some foods and medicines can affect how midostaurin works. Tell your doctor if you are using boceprevir, carbamazepine, clarithromycin, cobicistat, conivaptan, danoprevir/ritonavir, diltiazem, elvitegravir/ritonavir, enzalutamide, idelalisib, indinavir/ritonavir, itraconazole, ketoconazole, lopinavir/ritonavir, mitotane, nefazodone, nelfinavir, paritaprevir/ritonavir and (ombitasvir and/or dasabuvir), phenytoin, posaconazole, rifampin, ritonavir, saquinavir/ritonavir, St John's wort, tipranavir/ritonavir, troleandomycin, or voriconazole.
  • Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

Warnings While Using This Medicine:

  • This medicine may cause birth defects if either partner is using it during conception or pregnancy. Tell your doctor right away if you or your partner becomes pregnant. Use an effective birth control during treatment and for at least 4 months after your treatment ends. Also, you must have a negative pregnancy test within 7 days before starting this medicine.
  • Tell your doctor if you have kidney disease, liver disease, or lung problems.
  • Do not breastfeed during treatment and for at least 4 months after your last dose of this medicine.
  • Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
  • This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.
  • Cancer medicine can cause nausea or vomiting, sometimes even after you receive medicine to prevent these effects. Ask your doctor or nurse about other ways to control any nausea or vomiting that might happen.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Chest pain, trouble breathing

If you notice these less serious side effects, talk with your doctor:

  • Constipation, diarrhea, nausea, vomiting, or stomach pain
  • Cough, stuffy or runny nose, sore throat
  • Headache
  • Muscle or joint pain

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 10/10/2019

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