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Posaconazole (By mouth)

Posaconazole (poe-sa-KON-a-zole)

Treats or prevents fungus infections, especially in people who have a weak immune system.

Brand Name(s):


There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use if you had an allergic reaction to posaconazole or similar medicines.

How to Use This Medicine:

Liquid, Delayed Release Tablet

  • Your doctor will tell you how much medicine to use. Do not use more than directed.
  • Delayed-release tablet: Swallow the tablet whole. Do not crush, break, or chew it. Take this medicine with food.
  • Oral liquid:
    • Shake the oral liquid well before using. Use the dosing spoon in the package to measure the dose. Rinse the measuring spoon with water after use and before storage.
    • Take this medicine with a full meal or within 20 minutes after a meal. If you cannot eat a full meal, take it with a liquid nutritional supplement or an acidic drink, such as ginger ale.
  • Take all of the medicine in your prescription to clear up your infection, even if you feel better after the first few doses.
  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
  • Missed dose: Take your dose of medicine as soon as you remember. If it is less than 12 hours until your next dose, just skip the missed dose and go back to your regular schedule. Do not take extra medicine to make up for the missed dose.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Do not freeze the oral liquid.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Do not use this medicine together with atorvastatin, lovastatin, pimozide, quinidine, simvastatin, sirolimus, or an ergot medicine.
  • Some foods and medicines can affect how posaconazole works. Tell your doctor if you are using cimetidine, cyclosporine, digoxin, esomeprazole, glipizide, metoclopramide, phenytoin, rifabutin, tacrolimus, vinblastine, vincristine, medicine for HIV/AIDS (such as atazanavir, efavirenz, fosamprenavir, ritonavir), a sedative medicine (such as alprazolam, midazolam, triazolam), or blood pressure medicine (such as diltiazem, felodipine, nicardipine, nifedipine, verapamil).

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant or breastfeeding, or if you have a history of heart disease, kidney disease, liver disease, or heart rhythm problems (such as QT prolongation).
  • This medicine can cause the following problems:
    • Heart rhythm problems
    • Liver problems
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
  • Fast, slow, pounding, or uneven heartbeat
  • Severe diarrhea or vomiting
  • Unusual bleeding, bruising, or weakness

If you notice these less serious side effects, talk with your doctor:

  • Fever
  • Headache
  • Mild diarrhea, nausea, constipation

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 8/28/2020

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