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Atropine/edrophonium (By injection)

Atropine (AT-roe-peen), Edrophonium (e-droe-FOE-nee-um)

Reverses the effects of other medicines that relax muscles during surgery or other medical procedures.

Brand Name(s):


There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use it if you had an allergic reaction to atropine or edrophonium, or if you have glaucoma or a blockage that causes problems with your bowels or urination.

How to Use This Medicine:


  • Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.
  • A nurse or other health provider will give you this medicine.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Some medicines can affect how atropine/edrophonium works. Tell your doctor if you are taking digoxin or a beta-blocker, such as atenolol, metoprolol, or propranolol.
  • Dry mouth that is caused by this medicine can be made worse if you are also using other medicines that cause dry mouth. Examples include medicines to treat depression, Parkinson disease, motion sickness, cold or allergy symptoms, or stomach problems.

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant or breastfeeding, or if you have asthma or other breathing problems, heart disease, liver disease, heart rhythm problems, prostate problems, or myasthenia gravis.
  • Tell your doctor if you have a latex allergy. The stopper used on the medicine vial contains latex and may cause an allergic reaction.
  • Tell your doctor if you had an allergic reaction to sulfite, or if you have any other allergies.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blurred vision
  • Confusion, fast heartbeat
  • Fever, hot, dry skin without sweating
  • Increase in how much or how often you urinate
  • Lightheadedness or fainting
  • Muscle weakness or spasms
  • Nausea, vomiting, diarrhea, increased saliva
  • Problems with speech, walking, or swallowing
  • Slow heartbeat, shallow breathing

If you notice these less serious side effects, talk with your doctor:

  • Dry mouth
  • Increased sweating, watery eyes
  • Pain, itching, burning, swelling, or a lump under your skin where the needle is placed

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 8/28/2020

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites.

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