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Carisoprodol/aspirin/codeine (By mouth)

Aspirin (AS-pir-in), Carisoprodol (kar-eye-soe-PROE-dol), Codeine (KOE-deen)

Treats muscle pain and stiffness. This medicine contains an NSAID and a narcotic pain reliever.

Brand Name(s):

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use it if you had an allergic reaction to carisoprodol, codeine, aspirin, meprobamate, or other NSAIDs, or if you have severe lung or breathing problems (including asthma, nasal polyps, and rhinitis), hemophilia, Reye syndrome, porphyria, or stomach or bowel blockage (including paralytic ileus).

How to Use This Medicine:


  • Your doctor will tell you how much medicine to use. Do not use more than directed.
  • It is best to take this medicine with food or milk.
  • Drink plenty of liquids to help avoid constipation.
  • This medicine is not for long-term use. Do not use this medicine for more than 2 to 3 weeks (14 to 21 days) to treat pain unless your doctor has told you to.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Drop off any unused narcotic medicine at a drug take-back location right away. If you do not have a drug take-back location near you, flush any unused narcotic medicine down the toilet. Check your local drug store and clinics for take-back locations. You can also check the DEA web site for locations. Here is the link to the FDA safe disposal of medicines web site:

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Do not use this medicine if you are using or have used an MAO inhibitor within the past 14 days.
  • Some medicines can affect how this medicine works. Tell your doctor if you are using any of the following:
    • Acetazolamide, methotrexate, omeprazole, probenecid, quinidine, ritonavir, St John's wort, sulfinpyrazone
    • Blood pressure medicine (including atenolol, benazepril, enalapril, hydrochlorothiazide [HCTZ], lisinopril, metoprolol, propranolol)
    • Blood thinner (including apixaban, clopidogrel, enoxaparin, heparin, prasugrel, rivaroxaban, warfarin)
    • Diuretic (water pill)
    • Insulin or oral diabetes medicine (including glimepiride, glipizide, glyburide, metformin)
    • Medicine to treat depression (including bupropion, fluoxetine, fluvoxamine, mirtazapine, paroxetine, trazodone)
    • Medicine to treat infection (including erythromycin, ketoconazole, rifampin)
    • Medicine to treat seizures (including carbamazepine, phenytoin, valproic acid)
    • NSAID pain or arthritis medicine (including aspirin, celecoxib, diclofenac, ibuprofen, naproxen)
    • Phenothiazine medicine (including chlorpromazine, promethazine)
    • Steroid medicine (including dexamethasone, hydrocortisone, methylprednisolone, prednisolone, prednisone)
    • Triptan medicine to treat migraine headaches
  • Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol. Tell your doctor if you are using buprenorphine, butorphanol, nalbuphine, pentazocine, or a muscle relaxer. Tell your doctor if you drink 3 or more alcoholic beverages per day.

Warnings While Using This Medicine:

  • Tell your doctor if are pregnant or breastfeeding, or if you have kidney disease, liver disease, lung disease or breathing problems (including COPD, sleep apnea), heart disease, low blood pressure, pancreas or gallbladder problems, stomach ulcers, or trouble urinating. Tell your doctor if have a history of alcohol or drug abuse, brain tumor, head injury, depression, mental health problems, or seizures.
  • This medicine may cause the following problems:
    • High risk of overdose, which can lead to death
    • Respiratory depression (serious breathing problem that can be life-threatening)
    • Serotonin syndrome (when used with certain medicines)
    • Serious skin reactions
  • This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.
  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
  • This medicine may make you dizzy, drowsy, or lightheaded. Do not drive or do anything else that could be dangerous until you know how this medicine affects you. Sit or lie down if you feel dizzy. Stand up carefully.
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
  • This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.
  • This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation.
  • Call your doctor if your symptoms do not improve or if they get worse.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Bloody or black, tarry stools
  • Lightheadedness, dizziness, or fainting
  • Seizure, extreme sleepiness, trouble breathing, uneven, fast, slow, or shallow breathing, vomiting, confusion, pinpoint pupils
  • Severe constipation, stomach pain, nausea
  • Vomiting blood or material that looks like coffee grounds

If you notice these less serious side effects, talk with your doctor:

  • Restlessness or irritability
  • Trouble sleeping

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 3/19/2020

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