Gleason grading system
The Gleason grading system refers to how abnormal your prostate cancer cells look and how likely the cancer is to advance and spread. A lower Gleason grade means that the cancer is slower growing and not aggressive.
Prostate cancer - Gleason; Adenocarcinoma prostate - Gleason; Gleason score; Prostate cancer - 5 grade group
The first step in determining the Gleason grade is to determine the Gleason score.
Higher numbers indicate a faster growing cancer that is more likely to spread.
Currently the lowest score assigned to a tumor is grade 6. Scores below a 6 show normal to near normal cells. Most cancers have a Gleason score of between 5 and 7.
Gleason Grading System
Sometimes, it can be hard to predict how well people will do based just on their Gleason scores alone.
A new 5 Grade Group System has recently been created. This system is a better way to describe how a cancer will behave and respond to treatment.
A lower group indicates a better chance for successful treatment than a higher group. A higher group means that more of the cancer cells look different from normal cells. A higher group also means that it is more likely that the tumor will spread aggressively.
Grading helps you and your doctor determine your treatment options, along with:
Epstein JI. Pathology of prostatic neoplasia. In: Wein AJ, Kavoussi LR, Partin AW, Peters CA, eds. Campbell-Walsh Urology. 11th ed. Philadelphia, PA: Elsevier; 2016:chap 110.
Epstein JI, Zelefsky MJ, Sjoberg DD, et al. A contemporary prostate cancer grading system: a validated alternative to the Gleason score. Eur Urol. 2016;69(3):428-435. PMID: 26166626 www.ncbi.nlm.nih.gov/pubmed/26166626.
Gordetsky J, Epstein J. Grading of prostatic adenocarcinoma: current state and prognostic implications. Diagn Pathol. 2016;11:25. PMID: 26956509 www.ncbi.nlm.nih.gov/pubmed/26956509.
Review Date: 5/31/2018
Reviewed By: Sovrin M. Shah, MD, Assistant Professor, Department of Urology, The Icahn School of Medicine at Mount Sinai, New York, NY. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.