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Aflibercept (Into the eye)

Aflibercept (a-FLIB-er-sept)

Treats age-related macular degeneration, macular edema, and diabetic retinopathy.

Brand Name(s):


There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. You should not receive it if you had an allergic reaction to aflibercept, or if you are pregnant, or have an eye infection or active eye swelling.

How to Use This Medicine:


  • An eye doctor (ophthalmologist) will give you this medicine as a shot into the eye.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Warnings While Using This Medicine:

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant. Use an effective form of birth control before and during treatment with this medicine and for 3 months after the last dose.
  • Tell your doctor if you are breastfeeding, or if you have other eye problems or a history of blood clots, heart attack, or stroke.
  • This medicine may cause the following problems:
    • Eye problems, including a detached retina, eye swelling, increased pressure inside your eye
    • Increased risk of blood clots, heart attack, or stroke
  • This medicine may cause temporary blurred vision. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Bleeding in your eye
  • Chest pain, trouble breathing, coughing up blood
  • Eye pain or redness, trouble seeing, sensitivity to light, eyelid swelling, blurred vision
  • Numbness or weakness on one side of your body, sudden or severe headache, problems with vision, speech, or walking
  • Pain in your lower leg (calf)

If you notice these less serious side effects, talk with your doctor:

  • Floaters (seeing dark spots or lines in your field of vision), increased tearing
  • Pain, itching, burning, swelling, or redness where the shot is given

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 5/1/2020

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