Adapalene (On the skin)
DifferinThere may be other brand names for this medicine.
When This Medicine Should Not Be Used:
This medicine is not right for everyone. Do not use it if you had an allergic reaction to adapalene.
How to Use This Medicine:
Swab, Lotion, Solution, Cream, Gel/Jelly
- Your doctor will tell you how much medicine to use. Do not use more than directed. Extra medicine will not make it work faster and may cause red, peeling, or irritated skin.
- This medicine is usually applied in the evening.
- Wash your hands with soap and water before and after you use this medicine.
- Before you apply this medicine, wash your skin with water and a mild soap. Rinse well and pat dry.
- Apply a thin layer of the medicine to the affected area. Rub it in gently.
- Use this medicine only on your skin. Rinse it off right away if it gets on a cut or scrape. Do not get the medicine in your eyes, nose, or mouth. Do not apply to wind burned or sunburned skin.
- Missed dose: Apply a dose as soon as you can. If it is almost time for your next dose, wait until then and apply a regular dose. Do not apply extra medicine to make up for a missed dose.
- Store the medicine at room temperature, away from heat and direct light. Do not freeze.
Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Do not use any other medicines on the treated skin areas without asking your doctor. Do not use any skin care products that can dry or irritate your skin. These include rough skin cleansers, hair removal products, soaps or cosmetics that cause dryness, or products that contain alcohol, astringents, spices, or lime.
Warnings While Using This Medicine:
- Tell your doctor if you are pregnant or breastfeeding, or if you are sensitive to sunlight or have eczema.
- Use a moisturizer as needed if your skin becomes irritated.
- This medicine may make your skin more sensitive to sunlight, wind, and cold weather. Use sunscreen when you are outdoors, and wear protective clothing, such as a hat. Do not use a sunlamp or tanning bed.
- At first, your acne may seem to get worse before it gets better. Keep using the medicine as directed.
- Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
- Do not use this medicine to treat a skin problem your doctor has not examined. Do not use this medicine on skin that is sunburned or has active eczema.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Blistering, burning, crusting, dryness, or flaking of the skin
- Severe skin redness or swelling
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088Last Updated:
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites.
All rights reserved
A.D.A.M. content is best viewed in IE9 or above, Firefox and chrome browser.