Ursodiol (By mouth)
Dissolves gallstones when they cannot be removed by surgery. Also treats primary biliary cirrhosis (PBC), a liver disorder.
Actigall, URSO Forte, Urso 250There may be other brand names for this medicine.
When This Medicine Should Not Be Used:Do not use this medicine if you have had an allergic reaction to ursodiol or other bile acids. Do not use this medicine if you have biliary tract blockage, such as a blocked bile duct.
How to Use This Medicine:
- Take your medicine as directed.
- It is best to take this medicine with food or milk.
- Urso Forte® tablet can be broken in half, if needed. Place the tablet on a flat surface with the score (groove) on top. Hold the tablet with your thumbs close to the groove then apply gentle pressure until the tablet breaks apart. Swallow the half tablet with water. Do not chew.
- Gallstone treatment: Keep using the medicine for your full treatment time. It may take several months for the medicine to dissolve gallstones.
If a dose is missed:
- If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.
How to Store and Dispose of This Medicine:
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Half tablets can be used for up to 28 days when kept in the medicine bottle. Store half tablets separately from whole tablets, because the half tablets have a bitter taste.
- Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Make sure your doctor knows if you are also using an antacid that contains aluminum (ALternaGEL®, Gaviscon®, Maalox®, Mylanta®), medicine to lower cholesterol (such as cholestyramine, clofibrate, colestipol, Atromid-S®, Colestid®, Questran®), estrogen, or birth control pills.
Warnings While Using This Medicine:
- Make sure your doctor knows if you are pregnant or breastfeeding, or if you have other liver problems or pancreas problems.
- This medicine should not be used to treat bleeding varices, hepatic encephalopathy, or ascites.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Chest pain
- Fever, chills, cough, sore throat, and body aches
- Severe nausea and vomiting
- Severe stomach pain especially on the right upper side
- Swelling in your hands, ankles, or feet
- Unusual bleeding or bruising
If you notice these less serious side effects, talk with your doctor:
- Diarrhea, constipation, loss of appetite, upset stomach, or gas
- Indigestion or bitter taste in your mouth
- Itching, dry skin, rash, or hair thinning
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088Last Updated:
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