Acquired platelet function defect
Acquired platelet function defects are conditions that prevent clotting elements in the blood called platelets from working as they should. The term acquired means these conditions are not present at birth.
Acquired qualitative platelet disorders; Acquired disorders of platelet function
Platelet disorders can affect the number of platelets, how well they function, or both. A platelet disorder affects normal blood clotting.
Disorders that can cause problems in platelet function include:
Other causes include:
Symptoms may include any of the following:
Exams and Tests
Tests that may done include:
Treatment is aimed at fixing the cause of the problem:
Most of the time, treating the cause of the problem corrects the defect.
Complications may include:
When to Contact a Medical Professional
Call your health care provider if:
Using medicines as directed can reduce the risk of drug-related acquired platelet function defects. Treating other disorders may also reduce the risk. Some cases cannot be prevented.
Diz-Kucukkaya R, Lopez JA. Acquired disorders of platelet function. In: Hoffman R, Benz EJ Jr, Silberstein LE, Heslop HE, Weitz JI, Anastasi JI, eds. Hematology: Basic Principles and Practice. 6th ed. Philadelphia, PA: Elsevier Saunders; 2013:chap 132.
Hall JE. Hemostasis and blood coagulation. In: Hall JE, ed. Guyton and Hall Textbook of Medical Physiology. 13th ed. Philadelphia, PA: Elsevier; 2016:chap 37.
Jobe S, Di Paola J. Congenital and acquired disorders of platelet function and number. In: Kitchens CS, Kessler CM, Konkle BA, eds. Consultative Hemostasis and Thrombosis. 3rd ed. Philadelphia, PA: Elsevier Saunders; 2013:chap 10.
Review Date: 2/1/2017
Reviewed By: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
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