Acute lymphoblastic leukemia (ALL)
Acute lymphoblastic leukemia (ALL) is a fast-growing cancer of a type of white blood cell called a lymphoblast.
ALL occurs when the bone marrow produces a large number of immature lymphoblasts. Bone marrow is the soft tissue in the center of bones that helps form all blood cells. The abnormal lymphoblasts grow quickly and replace normal cells in the bone marrow. ALL prevents healthy blood cells from being made. Life-threatening symptoms can occur as normal blood counts drop.
ALL; Acute lymphoblastic leukemia; Acute lymphoid leukemia; Acute childhood leukemia; Cancer - acute childhood leukemia (ALL); Leukemia - acute childhood (ALL)
Most of the time, no clear cause can be found for ALL.
The following factors may play a role in the development of all types of leukemia:
The following factors are known to increase the risk of ALL:
This type of leukemia usually affects children ages 3 to 7. ALL is the most common childhood cancer, but it can also occur in adults.
ALL makes a person more likely to bleed and develop infections. Symptoms include:
These symptoms can occur with other conditions. Talk to the doctor about the meaning of specific symptoms.
Exams and Tests
A physical exam may reveal the following:
Blood tests may include:
Tests are also done to look for changes in the DNA inside the abnormal white cells. Certain DNA changes may determine how well a person does (prognosis), and what kind of treatment is recommended.
The first goal of treatment is to get blood counts back to normal. If this occurs and the bone marrow looks healthy under the microscope, the cancer is said to be in remission.
Chemotherapy is the first treatment tried with the goal of achieving a remission.
After a remission is achieved, more treatment is given to achieve a cure. This treatment can include more IV chemotherapy or radiation to the brain. Stem cell or bone marrow transplant from another person may also be done. Further treatment depends on:
You can ease the stress of illness by joining a cancer support group. Sharing with others who have common experiences and problems can help you not feel alone.
Those who respond to treatment right away tend to do better. Most children with ALL can be cured. Children often have a better outcome than adults.
Both leukemia itself and the treatment can lead to many problems such as bleeding, weight loss, and infections.
When to Contact a Medical Professional
Call your health care provider if you or your child develops symptoms of ALL.
The risk of developing ALL may be reduced by avoiding contact with certain toxins, radiation, and chemicals.
Jeha S, Pui CH. Clinical manifestations and treatment of acute lymphoblastic leukemia in children. In: Hoffman R, Benz EJ Jr, Silberstein LE, Weitz JI, Anastasi J, eds. Hematology: Basic Principles and Practice. 6th ed. Philadelphia, PA: Elsevier Saunders; 2013: chap 64.
National Cancer Institute: PDQ Adult Acute Lymphoblastic Leukemia Treatment. Bethesda, Md: National Cancer Institute. Date last modified January 13, 2015. Available at: www.cancer.gov/cancertopics/pdq/treatment/adultALL/HealthProfessional. Accessed: February 26, 2015.
National Cancer Institute: PDQ Childhood Acute Lymphoblastic Leukemia Treatment. Bethesda, Md: National Cancer Institute. Date last modified January 28, 2015. Available at: cancer.gov/cancertopics/pdq/treatment/childALL/HealthProfessional. Accessed: February 26, 2015.
National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Acute Lymphoblastic Leukemia. Version 2.2014. Available at: /www.nccn.org/professionals/physician_gls/pdf/all.pdf. Accessed: February 26, 2015.
Review Date: 2/13/2015
Reviewed By: Rita Nanda, MD, Assistant Professor of Medicine, Section of Hematology/Oncology, University of Chicago Medicine, Chicago, IL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.
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